Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

PT-141 (10mg x 10)

Name: PT-141 (10mg x 10)
SKU: 11885
Availability: InStock

$425.00

PT-141 is a synthetic research peptide structurally derived from the melanocortin analog Melanotan II. It is studied for its selective binding activity at melanocortin receptors MC3R and MC4R and its role in modulating neuropeptide-mediated signaling pathways.

In experimental systems, PT-141 is commonly used to investigate G protein–coupled receptor (GPCR) activation, neuronal signaling dynamics, and mechanisms related to neuroendocrine regulation under controlled laboratory conditions.

For research use only. Not intended for human or animal use.

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Properties

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Overview

PT-141 is a synthetic research peptide structurally derived from the melanocortin analog Melanotan II. It is studied for its selective binding activity at melanocortin receptors MC3R and MC4R and its role in modulating neuropeptide-mediated signaling pathways.

In experimental systems, PT-141 is commonly used to investigate G protein–coupled receptor (GPCR) activation, neuronal signaling dynamics, and mechanisms related to neuroendocrine regulation under controlled laboratory conditions.

For research use only. Not intended for human or animal use.

Biochemical

Sequence: Gly-His-Lys (Cu²⁺)

Molecular Formula: C62H98N16022

Molecular Weight: 402.92 g/mol

PubChem CID: 71587328

Research Applications

GHK-Cu is widely used in laboratory research to study fibroblast migration, immune cell recruitment, angiogenic signaling pathways, and extracellular matrix synthesis. Common experimental models include dermal fibroblast cultures, endothelial cell–based assays, neuronal regeneration frameworks, and controlled preclinical animal studies.

Additional research applications involve the investigation of oxidative stress modulation, antimicrobial peptide interactions, stem-cell–associated signaling markers, and transcriptional responses linked to tissue remodeling and regenerative processes under controlled experimental conditions.

Mechanistic Context

Mechanistic investigations suggest that GHK-Cu influences multiple biochemical pathways, including integrin-mediated signaling, regulation of transforming growth factor-β (TGF-β), modulation of pro-inflammatory cytokine activity, and activation of antioxidant response elements.

Gene expression analyses further indicate that GHK-Cu affects transcriptional networks involved in cellular migration, extracellular matrix turnover, neuronal viability, and redox homeostasis. Copper sequestration by the peptide may reduce metal-catalyzed oxidative stress, thereby altering downstream signaling cascades under controlled experimental conditions.

Preclinical Research Summary

Preclinical investigations of GHK-Cu include in-vitro fibroblast and keratinocyte models, neuronal regeneration assays, antimicrobial interaction studies, and multiple in-vivo animal models of tissue injury and inflammation.

Experimental observations report enhanced cellular migration, increased extracellular matrix deposition, modulation of inflammatory mediators, and altered gene-expression patterns associated with regeneration and stress response. These findings are presented solely as laboratory observations without implication of clinical, cosmetic, or therapeutic outcomes.

Form & Analytical Testing

GHK-Cu is supplied as a synthetic, research-grade peptide complex. Product identity and purity are verified using validated analytical methods, including high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Batch-specific analytical documentation is provided where applicable.

Referenced Citations

1. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

2. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

3. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

4. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

5. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, pp. 2485–2499, 2015.

RUO Disclaimer

TB-500 is a research peptide corresponding to a 43-amino-acid sequence derived from Thymosin Beta-4, an actin-binding protein involved in cytoskeletal organization and cellular regeneration. It is studied for its role in regulating actin dynamics and cell motility.

Preclinical studies indicate that TB-500 influences cell migration, angiogenic signaling, and actin polymerization through modulation of the β-actin/G-actin cycle and associated growth-factor pathways. As a research compound, it is commonly used to investigate wound repair mechanisms, cellular movement, and peptide-mediated regenerative processes under controlled experimental conditions.

For research use only. Not intended for human or animal use.

Storage Instructions

All products are manufactured using a lyophilization (freeze-drying) process, which enhances stability during storage and transport. When stored properly, lyophilized peptides remain stable for shipping for up to 3 to 4 months.

Lyophilization, also known as cryodesiccation, is a dehydration process in which peptides are first frozen and then exposed to reduced pressure. This allows water to sublimate directly from solid to gas, leaving behind a stable, crystalline white solid commonly referred to as a lyophilized peptide. In this form, peptides may be stored at room temperature until reconstitution.

Once reconstituted with bacteriostatic water, peptides must be stored under refrigeration to maintain stability. After reconstitution, refrigerated peptides are generally stable for up to 30 days.

Upon receipt, peptides should be kept cold and protected from light. For short-term storage (days to weeks), refrigeration at or below 4°C (39°F) is recommended. Lyophilized peptides are typically stable at room temperature for short durations; however, refrigeration is preferred when possible.

For long-term storage (several months to years), peptides should be stored frozen. Deep freezing at −80°C (−112°F) is optimal for preserving peptide stability over extended periods.

PT-141 (10mg x 10)

Properties

Molecular Formula

Molecular Weight

Monoisotopic Mass

Polar Area

Complexity

XLogP

Heavy Atom Count

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

Rotatable Bond Count

PubChem LCSS

2D Structure

Identifiers

CID

InChI

IUPAC Name

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